CRITICAL ROLE OF p38α IN INDUCING SYNAPTIC AND COGNITIVE DYSFUNCTION
NORTHWESTERN UNIVERSITY PRESS RELEASE, JUNE 26, 2013:
"The target is a stress-related protein kinase, p38alpha MAPK. Recent neuroscience research has shown that the target is activated in neurological disorders such as Alzheimer’s.…The over-activated protein kinase p38 MAPK damages the wiring of the communication network within the brain. Neurons communicate with other neurons at structures called synapses. Over activation of p38 MAPK damages the synapses and alters the normal functioning of neurons, impairing communication…..(p38 alpha inhibition) prevented impairment of the synapse in the mouse brain exposed to amyloid beta."
TEMPLE UNIVERSITY PRESS RELEASE, JANUARY 27, 2017
“…we found that memory impairment was directly associated with increased p38 activation."
“The findings are very exciting" Dr.Domenico Pratico MD ( Professor for Translational Medicine at the
Lewis Katz School of Medicine at Temple University) said. "There is now a lot of evidence to suggest that
p38 is involved in the development of Alzheimer's disease.”
"It is an exciting avenue of research. A drug targeting this protein could bring big benefits for patients,"