EIP Pharma, LLC is a private company that has licensed-in and is developing neflamapimod (previously code-named VX-745), a phase 2 clinical-stage oral investigational drug that inhibits the enzyme p38 MAP Kinase alpha and in doing so blocks the effects of amyloid-beta and inflammation on neuronal and synaptic function.
EIP Pharma licensed neflamapimod in 2012 and has conducted animal studies to position the drug as a treatment for diseases of the brain, including Alzheimer's diseases. Neflamapimod had previously completed a full chronic toxicology program and had demonstrated significant clinical and anti-inflammatory activity in a phase 2a 12-week treatment study in rheumatoid arthritis (RA). Phase 2a clinical studies in patients with Early Alzheimer's disease with were started in May 2015 in the Netherlands and in the US, and completed in September 2016.
EIP Pharma has made a number of discoveries related to neflamapimod that are reflected in three issued US patents on the administration of neflamapimod (VX-745) owned by the company: (1) US #9,427,438, issued August 2016, to treat patients suffering from Alzheimer’s disease, (2) US #8,697,627, issued April 2014, to lower brain amyloid plaque load (also issue in EU and Japan), and (3) US #9,427,439, issued August 2016, to promote recovery of function in patients who have suffered acute neurologic injury, including that resulting from acute ischemic stroke. Additional patents have been filed in the US and internationally.
Company was founded and is led by experienced biotech/pharma R&D executive with extensive translational and drug development experience & expertise in both inflammation and CNS disorders. EIP Pharma achieves its objectives by working with a network of select expert consultants, vendors and contract research organizations with specific expertise in developing neurologic therapeutics. This virtual structure is designed to provide maximal innovative capacity by providing capital efficiency, scientific excellence and the ability to respond rapidly to new findings and data during the development process.
Founder and CEO
John Alam is an industry leader in translational medicine and has a track record of creating value to help build companies through clinical development success.
Until May 2014, he was therapeutic area head for diseases of aging within Sanofi R&D. In that role he led all discovery and development activities at Sanofi directed at Alzheimer’s disease, as well as a number of other age-related diseases (Sarcopenia/Frailty, Osteoarthritis, Chronic Pain, others).
Previously, from 1997 until 2008 he held positions of increasingly responsibility at Vertex Pharmaceuticals, Inc., including Chief Medical Officer and Executive Vice President Medicines Development. At Vertex, he played major roles in the development of novel innovative medicines for HIV, Hepatitis C and Cystic Fibrosis. And, from 1991 to 1997, at Biogen, Inc, he led the clinical development of Avonex (interferon beta-1a) for multiple sclerosis.
John currently is also senior medical advisor at MetrioPharm AG, a listed Swiss-German pharmaceutical company that is developing a peripherally acting anti-inflammatory drug. He is also a member of the board of directors of Alliance for Aging Research (AAR), a Washington DC based non-profit organization dedicated to promoting innovation to address the healthcare needs of older Americans. Among other activities AAR convenes ACT-AD ("Accelerate Cures/Treatments for Alzheimers Disease"), a public-private partnership focused on accelerating the development of treatments that slow, halt or reverse the progression of Alzheimers disease.
John received a S.B. in chemical engineering from the Massachusetts Institute of Technology and a M.D. from Northwestern University School of Medicine. Subsequently, he completed an internal medicine residency at Brigham and Women’s Hospital and a post-doctoral fellowship at Dana-Farber Cancer Institute.
Sylvie Grégoire is former president of Human Genetic Therapies at Shire Pharmaceuticals, 2007 to 2013. Prior to that, from 2006 to 2007 she was executive chairman of IDM Pharma Inc., and from 2003 to 2004 president and chief executive officer in GlycoFi Inc. From 1995 until 2003 Dr. Grégoire held various leadership positions in Biogen, Inc, most recently as executive vice president of Technical Operations. Prior to Biogen, Dr Grégoire was at Merck and Co, in clinical research and regulatory affairs for a period of 8 years. Dr. Grégoire currently serves as Chair of the Board at Corvidia, Inc and Executive Chair at Metriopharm AG; and is a also member of the Board of Directors at Novo Nordisk A/S , Galenica AG and Perkin Elmer Corporation.
Dr. Grégoire has a Pharmacy Doctorate degree from the State University of NY at Buffalo, a B.A. in Pharmacy from Laval University, Canada, and a Science College degree from Seminaire de Sherbrooke, Canada.